Directed DNA deamination by AID/APOBEC3 in immunity
نویسندگان
چکیده
Several hundred papers in the past seven years have established two new mechanisms of immunity, both of which are dependent upon proteins that deaminate cytosines to uracils within singlestranded DNA. Activation-induced deaminase (AID) deaminates C -> U to implement the diversification of vertebrate antibody genes and mammalian APOBEC3 proteins, such as human APOBEC3F and APOBEC3G, deaminate C -> U to trigger the destruction of a wide variety of retroelements including HIV. Here, we will discuss how the purposeful deamination of DNA-based cytosines underpins integral parts of both the adaptive and the innate immune responses.
منابع مشابه
AID can restrict L1 retrotransposition suggesting a dual role in innate and adaptive immunity
Retrotransposons make up over 40% of the mammalian genome. Some copies are still capable of mobilizing and new insertions promote genetic variation. Several members of the APOBEC3 family of DNA cytosine deaminases function to limit the replication of a variety of retroelements, such as the long-terminal repeat (LTR)-containing MusD and Ty1 elements, and that of the non-LTR retrotransposons, L1 ...
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ورودعنوان ژورنال:
- Current Biology
دوره 16 شماره
صفحات -
تاریخ انتشار 2006